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Xiapex Injections

Xiapex is a treatment that has recently become available for sufferers of Dupuytren's Contracture. It is the trade name of a particular type of enzyme (collagenase) that can help dismantle the structures that cause the tightening of connective tissue in the palm of the hand. The enzyme is produced in a laboratory from the bacterium Clostridium histolyticum. It is provided to us in a form that can be dissolved and injected below the skin at the site requiring treatment.

What can be treated with Xiapex injections?

Xiapex is intended to treat cases of Dupuytren's contracture, also known as Dupuytren's' disease, a condition that causes the fingers to bend towards the palm of the hand. This condition, described in more detail on another page, can case a loss of dexterity and function.
The main cause of Dupuytren's' disease is a thickening and contracture of the connective tissue in the palm of the hand. In some cases, this can be seen as visible 'nodules' in the palm of the hand. By breaking down the build-up of collagen, Xiapex injections can help the fingers return to a normal range of movement.

What is the procedure for Xiapex treatment?

Xiapex injections are performed as an outpatient procedure. The Xiapex enzyme solution is injected into the hand at the location of the Dupuytren's' contracture. Within 48 hours it should be possible for us to straighten your finger under local anaesthetic. The collagen continues to break down and the enzyme is itself broken down by the body. A successful treatment should see restoration of an acceptable range of movement within one or two weeks.

Find out more about Xiapex injections

If you are interested in this treatment, which is intended only for properly diagnosed adult cases of Dupuytren's' contracture, please get in touch and make an appointment. We can discuss the procedure, clear up any concerns over potential side effects and answer your questions about Xiapex. To begin with you will need to have the condition assessed and the range of treatments discussed. Please call us to find a suitable time for an appointment.